City of Hope Leads AI-Powered Health Care Innovations and Launches Generative AI Tool to Save Lives and Enable Nationwide Best-in-Class Cancer Care

• City of Hope has engineered, rigorously validated and fine-tuned a generative AI platform, leveraging the national cancer center’s extensive oncology data and expertise.
• The app, HopeLLM, removes the administrative burden of new patient onboarding, matches patients to clinical trials, enables generative AI responses that are personalized to individual patient records and extracts real-world data for research.
• HopeLLM enhances provider and patient experiences, accelerates breakthrough research and widens access to world-class cancer care, ultimately saving lives.

City of Hope^®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center named a Top 5 “Best Hospital” in the nation for cancer care by U.S. News & World Report, is using generative artificial intelligence to create operational efficiency, enable AI-driven patient personalization, improve access to clinical trials and empower breakthrough research.

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City of Hope announced Hope LLM, a novel generative AI platform that leverages multiple commercial and open-source AI models.

“With the rise of AI, health care systems like City of Hope are seizing the opportunity to transform physician workloads and fuel more focused, personalized patient care,” said Simon Nazarian, City of Hope chief digital and technology officer and system executive vice president.

Among City of Hope’s most exciting health care innovations is a novel generative AI platform that leverages multiple commercial and open-source AI models. HopeLLM — powered by City of Hope’s proprietary technology and data — removes the administrative burden of new patient onboarding, matches patients to clinical trials, enables generative AI responses personalized to individual patient records and extracts real-world data for research.

“By summarizing massive information in seconds, HopeLLM removes a barrier between the patient and the doctor. Instead of spending time finding information in the history of previous tests and treatments, doctors can spend time and effort in getting patients and caregivers to understand treatment options. Instead of the frustration of trying to find information, doctors are able to create more joy as they deliver patient care,” said Vijay Trisal, M.D., City of Hope system chief clinical officer and the Dr. Norman & Melinda Payson Professor in Medicine.

HopeLLM, is a revolutionary time saver that may be used by clinicians across City of Hope’s national clinical network, enabling patients to receive world-class cancer care regardless of which City of Hope location they visit. In 2024 alone, City of Hope onboarded more than 150,000 patients. Doctors often see new patients with extensive medical histories spanning 10 to 20 years of test results, notes and treatment reports. Doctors need to spend significant time — often during nonworking hours — to review hundreds of pages, leading to less time interacting directly with patients.

Additionally, HopeLLM instantly points out a patient’s clinical trial eligibility and automatically extracts key data points into research-ready formats, converting hours of manual chart review into seconds of AI-driven insight.

“We’re not just building point solutions; we have built the engine for a learning health system where every patient interaction accelerates the next breakthrough,” says Nasim Eftekhari, M.S., City of Hope chief AI and analytics officer and system vice president.

Since 2017, City of Hope has been developing, deploying and optimizing life-saving AI-driven predictive models that are actively integrated into clinical workflows. These AI models help identify critical risks — such as sepsis in vulnerable populations and complications in surgical procedures — enabling timely clinical interventions that enhance patient outcomes and improve patient quality of life. Importantly, these predictive models provide risk scores along with contextual explanations that clarify the factors driving the prediction, empowering responsible AI-driven clinical decision-making support.

City of Hope’s pioneering AI initiatives extend to oncology drug discovery, early cancer detection and prevention, advanced diagnostics and deeper insights into cancer evolution and disease progression. As an organization that both develops and uses AI tools, City of Hope is committed to harnessing artificial intelligence to enhance patient care, advance research and improve health care efficiency.

HopeLLM exemplifies City of Hope’s AI work, where people with cancer benefit directly. For example, patients and doctors typically share the burden of providing and verifying medical history. However, HopeLLM shifts this responsibility away from patients, helping them to receive more personalized care and engage in focused, future-looking discussions with their doctors. HopeLLM allows patients to concentrate on their primary responsibility: recovery.

To receive a second opinion at City of Hope Los Angeles, call 888-720-1621 or visit this webpage.

About City of Hope

City of Hope's mission is to make hope a reality for all touched by cancer and diabetes. Founded in 1913, City of Hope has grown into one of the largest and most advanced cancer research and treatment organizations in the United States, and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked a Top 5 “Best Hospital” in the nation for cancer care by U.S. News & World Report at its core, City of Hope’s uniquely integrated model spans cancer care, research and development, academics and training, and a broad philanthropy program that powers its work. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix areas. City of Hope’s affiliated group of organizations includes Translational Genomics Research Institute and AccessHope^TM. For more information about City of Hope, follow us on Facebook, X, YouTube, Instagram and LinkedIn.

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City of Hope is using generative artificial intelligence to create operational efficiency, enable AI-driven patient personalization, improve access to clinical trials and empower breakthrough research.