UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    Form 8-K

                                 Current Report

     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): March 23, 2007

                              Alfacell Corporation
             (Exact name of registrant as specified in its charter)

                                     0-11088
                            (Commission File Number)

         Delaware                                    22-2369085
  (State or other jurisdiction of       (I.R.S. Employer Identification No.)
   incorporation)

               225 Belleville Avenue, Bloomfield, New Jersey 07003
             (Address of principal executive offices, with zip code)

                                 (973) 748-8082
              (Registrant's telephone number, including area code)

                                 Not Applicable
          (Former name or former address, if changed since last report)

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     [ ]  Written  communications  pursuant to Rule 425 under the Securities Act
          (17 CFR 230.425)

     [ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
          CFR 240.14a-12)

     [ ]  Pre-commencement  communications  pursuant to Rule 14d-2(b)  under the
          Exchange Act (17 CFR 240.14d-2(b))

     [ ]  Pre-commencement  communications  pursuant to Rule 13e-4(c)  under the
          Exchange Act (17 CFR 240.13e-4(c))


ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT

On March 23, 2007,  Alfacell  Corporation (the "Company") entered into an Office
Lease Agreement (the "Lease"), effective as of March 14, 2007, with I & G Garden
State,  L.L.C., a Delaware limited liability  company (the "Landlord"),  whereby
the Company has leased 15,410 square feet of office and laboratory  space in the
building located at 300 Atrium Drive, Somerset, New Jersey (the "Building"). The
new office will replace 225  Belleville  Avenue,  Bloomfield,  New Jersey as the
Company's principal executive offices.

The lease term will begin when the Landlord  delivers  possession to the Company
(the "Commencement Date"), targeted to be on approximately July 1, 2007, and the
termination  date is set for the 150th day  after the tenth  anniversary  of the
Commencement  Date. The Lease also includes an option to renew the lease for two
additional periods of 60 months each, with the rent for such option period equal
to the prevailing market rate for renewals at the time.

The Company  will be required  to pay base rent and  additional  rent during the
lease term.  Additional  rent will be equal to the  Company's  pro rata share of
certain basic costs and utilities as set forth in the Lease,  and base rent will
be paid in accordance with the following schedule:


                         

------------------------------------------------- ------------------------- ------------------------------------------
                     Period                           Annual Base Rent          Monthly Installments of Base Rent
------------------------------------------------- ------------------------- ------------------------------------------
First day of first Lease Year  through  last day        $137,280.00                        $11,440.00
of the first Lease Year                                                        ($11.44 x 12,000 square feet / 12)
------------------------------------------------- ------------------------- ------------------------------------------
First day of second Lease Year through 540 days         $235,200.00                        $19,600.00
from Commencement Date or the day before first                                 ($19.60 x 12,000 square feet / 12)
day of the 19th month of the Lease
------------------------------------------------- ------------------------- ------------------------------------------
 540 days from  Commencement  Date or day before        $302,036.04                        $25,169.67
first day of 19th  month of Lease  through  last                               ($19.60 x 15,410 square feet / 12)
day of the third Lease Year
------------------------------------------------- ------------------------- ------------------------------------------
First day of fourth  Lease Year  though last day        $317,445.96                        $26,453.83
of the sixth Lease Year                                                        ($20.60 x 15,410 square feet / 12)
------------------------------------------------- ------------------------- ------------------------------------------
First day of the  seventh  Lease Year though the        $332,856.00                        $27,738.00
last day of the eighth Lease Year                                              ($21.60 x 15,410 square feet / 12)
------------------------------------------------- ------------------------- ------------------------------------------
First day of ninth  Lease Year  through the last        $355,971.00                        $29,664.25
day of the Lease Term                                                          ($23.10 x 15,410 square feet / 12)
------------------------------------------------- ------------------------- ------------------------------------------





In  connection  with  execution of the Lease,  the Company was required to enter
into a Subordination,  Non-Disturbance  and Attornment  Agreement with Asset One
Securitization, L.L.C. (the  "Lender"), and the Landlord,  pursuant to which the
Company  has  agreed to  subordinate  its  Lease to the  mortgage  and  security
instrument  on the  Building  owned by  Lender  in return  for  Lender  granting
non-disturbance to the Company under the Lease.

The  foregoing  description  is  qualified  in its  entirety by reference to the
Lease,  which will be filed as an exhibit to the Company's next quarterly report
on Form 10-Q.



                                      -2-



                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                     ALFACELL CORPORATION


Date:  March 28, 2007                By:  /s/ Lawrence A. Kenyon
                                        ----------------------------------------
                                             Lawrence A. Kenyon
                                             Executive Vice President, Chief
                                             Financial Officer and Secretary