UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

     Date of report (Date of earliest event reported): OCTOBER 31, 2005   
                                                      --------------------------

                               ENZO BIOCHEM, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    NEW YORK
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                 (State or Other Jurisdiction of Incorporation)

                  001-09974                               13-2866202
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          (Commission File Number)             (IRS Employer Identification No.)

        60 EXECUTIVE BOULEVARD
         FARMINGDALE, NEW YORK                                11735
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  (Address of Principal Executive Offices)                 (Zip Code)

                                 (631) 755-5500
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              (Registrant's Telephone Number, Including Area Code)

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          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))






ITEM 1.01.        ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

         On October 31, 2005, the Board of Directors of Enzo Biochem,  Inc. (the
"Company") voted to (a) create the position of Lead Independent  Director of the
Board of  Directors,  (b)  elect  Melvin F.  Lazar to serve as Lead  Independent
Director,  effective immediately,  (c) adopt a Lead Independent Director Charter
and (d) adopt  amendments  to the  Company's  amended and  restated  bylaws (the
"Bylaws"), effective immediately, among other things, to add provisions relating
to the position of Lead Independent Director.

         Upon the  recommendation of the Compensation  Committee of the Board of
Directors,  the  Board  of  Directors  also  adopted  changes  to  the  existing
non-employee director fee schedule described in the Company's proxy statement on
Schedule 14A, as amended,  filed with the Securities and Exchange  Commission on
January  19,  2005,  effective  for any Board of  Directors  or Board  committee
meetings held on or after October 31, 2005.

         As an annual fee, the Lead  Independent  Director will receive  $50,000
per year and all other non-employee directors will receive $20,000 per year. For
each meeting of the Board of Directors  attended in person or by telephone,  the
Lead Independent  Director and all other  non-employee  directors will receive a
fee  of  $2,000.  Additionally,  each  non-employee  director  who  serves  on a
committee  of the Board of  Directors  will  receive  a fee of  $1,000  for each
meeting of the committee attended in person or by telephone.  In addition to the
$1,000 per  committee  meeting fee, the  Chairman of the Audit  Committee  shall
receive  an  additional  fee of $1,000 for each  meeting of the Audit  Committee
attended in person or by telephone,  the Lead Independent Director shall receive
an additional  fee of $500 for each meeting of any Board  committee  attended in
person or by telephone,  and the Chairman of the Compensation  Committee and the
Chairman of the Nominating/Governance Committee shall each receive an additional
fee of  $500  for  each  meeting  of the  committee  attended  in  person  or by
telephone.  The Lead Independent  Director will receive 10,000  restricted stock
units immediately following the date of the next annual meeting of the Company's
shareholders,  provided  such  person is a director of the Company at such time.
All other  non-employee  directors  will receive  5,000  restricted  stock units
immediately  following  the date of the next  annual  meeting  of the  Company's
shareholders,  provided  such  person is a director of the Company at such time.
Each of the  restricted  stock  units  referred  to above  shall be subject to a
two-year  vesting period;  provided that at the time any  non-employee  director
ceases to be a director of the Company, such non-employee  director's restricted
stock units shall become fully vested at such time. Such  restricted  stock unit
grants will be made in lieu of the  automatic  annual  stock  option  grants the
non-employee  directors  would have received at such time under the terms of the
Company's 2005 Equity  Compensation  Incentive  Plan. The Company will reimburse
directors  for their travel and related  expenses in connection  with  attending
meetings of the Board of Directors and Board-related activities.

         The revised  non-employee  director  compensation  summary  schedule is
included as Exhibit 10.1 to this Current  Report on Form 8-K ("Current  Report")
and is incorporated by reference in its entirety into this Item 1.01.






ITEM 5.03.   AMENDMENTS TO ARTICLES OF INCORPORATION OR BYLAWS; CHANGE IN FISCAL
             YEAR.

         Effective  October  31,  2005,  the Board of  Directors  of the Company
adopted the following amendments to the Bylaws:

         A new  Section 16 of  Article  II has been  added to the  Bylaws  which
provides  that the Board of Directors  may from time to time elect a director to
serve as Lead Independent Director,  which shall be an "independent director" in
accordance  with the Securities  Exchange Act of 1934, as amended (the "Exchange
Act"), and the rules promulgated  thereunder and the applicable rules of the New
York Stock Exchange.  The amendment provides that the Lead Independent Director,
if one be elected,  shall,  if present,  preside at each meeting of the Board of
Directors  in the case of the absence or inability to act of the Chairman of the
Board of the  Company,  and when so acting  shall have all the powers of, and be
subject to all the restrictions  upon, the Company's  Chairman of the Board, and
shall coordinate the activities of the independent  directors of the Company and
have such other  authority and powers as the Board of Directors may from time to
time prescribe.

         The duties of the Lead Independent  Director,  as set forth in the Lead
Independent  Director  Charter  adopted by the Board of Directors on October 31,
2005,  among  other  things,  are to (a)  develop  the  agendas for and serve as
chairman of the executive sessions of the independent  directors of the Company;
(b) serve as principal liaison between the independent  directors of the Company
and the Chairman of the Board and between the  independent  directors and senior
management;  (c)  provide  the  Chairman  of  the  Board  with  input  as to the
preparation  of the agendas for Board  meetings;  (d) advise the Chairman of the
Board as to the quality, quantity and timeliness of the information submitted by
the Company's  management  that is necessary or appropriate  for the independent
directors to effectively and responsibly  perform their duties;  (e) ensure that
independent directors have adequate  opportunities to meet and discuss issues in
executive sessions without management present;  (f) if the Chairman of the Board
is unable to attend a Board of Directors meeting,  act as chairman of such Board
of  Directors  meeting;  and (g)  perform  such  other  duties  as the  Board of
Directors  shall from time to time  delegate.  On October 31, 2005, the Board of
Directors  elected  Melvin F. Lazar to serve as the Lead  Independent  Director,
effective immediately.

         Section 9 of Article II of the Bylaws has also been  amended to provide
that if the  Chairman of the Board is not present at any meeting of the Board of
Directors,  the  meeting  shall be led by the  Lead  Independent  Director.  The
amended  provision  also provides that (a) in the absence of the Chairman of the
Board and the Lead  Independent  Director,  the Vice Chairman of the Board shall
act as chairman of the meeting, (b) in the absence of the Chairman of the Board,
the Lead Independent  Director and the Vice Chairman of the Board, the President
shall act as  chairman  of the  meeting  and (c),  in the  absence of all of the
foregoing  individuals,  another  director chosen by a majority of the directors
present  shall act as chairman of the meeting.  The previous  provision  did not
provide for the Lead  Independent  Director and the Vice  Chairman of the Board,
and allowed for the President or, in his absence,  another  director chosen by a
majority of the  directors  present to preside if the  Chairman of the Board was
not present.

         Section 6 of Article II has also been  amended to provide  that special
meetings of the Board of Directors may be called by two or more directors of the
Company or by the Chairman 



of the Board, the Lead Independent  Director,  the Vice Chairman of the Board or
the  President.  The previous  provision  provided that special  meetings of the
Board of Directors  may be called by two or more  directors of the Company or by
the Chairman of the Board or the President.

         Section  5.a.  of Article IV has been  amended to delete the  provision
that the Chairman of the Board "shall be an ex officio member of all committees"
of the Board of Directors.

         Section  5.b. of Article IV has been  amended to provide  that the Vice
Chairman of the Board,  if one be elected,  shall,  if present,  preside at each
meeting of the  shareholders  in the case of the absence or  inability to act of
the Chairman of the Board, and shall, if present, preside at each meeting of the
Board  of  Directors  in the  case of the  absence  or  inability  to act of the
Chairman  of the Board and the Lead  Independent  Director,  and shall have such
other  authority and powers and perform all such duties as from time to time may
be assigned to him by the Board of Directors  or the Chairman of the Board.  The
previous  Section  5.b. of Article IV did not  provide for the Lead  Independent
Director and provided  that the Vice  Chairman of the Board,  if one be elected,
shall in the case of the  absence or  inability  to act of the  Chairman  of the
Board, perform the duties of the Chairman of the Board.

         Section 6 of Article IV has been amended to provide that the  President
shall be the chief  operating  officer of the Corporation and shall have general
and active  supervision  and  direction  over the  business  and  affairs of the
Corporation and over its several officers, subject, however, to the direction of
the  Chairman  of the  Board and the  control  of the  Board of  Directors.  The
provision  further  provides,  among other  things,  that he shall,  if present,
preside  at each  meeting  of the  shareholders  in the case of the  absence  or
inability to act of the Chairman of the Board and the Vice Chairman of the Board
and, if present,  preside at each  meeting of the Board of Directors in the case
of the  absence or  inability  to act of the  Chairman  of the  Board,  the Lead
Independent  Director and the Vice Chairman of the Board. The previous Section 6
of Article IV did not provide for the Lead  Independent  Director and  provided,
among other things,  that at the request of the Chairman of the Board, or in the
case of his absence or inability to act (unless  there be a Vice Chairman of the
Board so  designated  to act),  the  President  shall  perform the duties of the
Chairman of the Board.

         Section 6 of Article I has been amended to provide, among other things,
that at each meeting of the  shareholders  of the  Company,  the Chairman of the
Board, or in his absence or inability to act, the Vice Chairman of the Board, or
in the  absence or  inability  to act of the  Chairman of the Board and the Vice
Chairman of the Board,  the President,  or in the absence or inability to act of
the Chairman of the Board,  the Vice Chairman of the Board and the President,  a
Vice President, or in the absence of all of the foregoing,  any person chosen by
a majority of those shareholders present,  shall act as chairman of the meeting.
The previous Section 6 of Article I did not provide for the Vice Chairman of the
Board.

         Section 1 of  Article I has been  amended  to  provide  that the annual
meeting of shareholders of the Company for the election of directors and for the
transaction  of such other business as may come before the meeting shall be held
during the sixth month  following  the close of the Company's  fiscal year.  The
previous Section 1 of Article I provided that the annual



meeting  of  shareholders  be held on the third  Wednesday  of the  fifth  month
following the close of the Company's fiscal year.

         The Bylaws,  as amended and  restated as of October 31,  2005,  and the
Enzo Biochem,  Inc. Lead  Independent  Director Charter are included as Exhibits
3.1 and 99.2,  respectively,  to this Current  Report,  and are  incorporated by
reference in their entirety into this Item 5.03.

ITEM 8.01.        OTHER EVENTS.

         On November 4, 2005, the Company  announced that the Board of Directors
voted to (a) create the  position of Lead  Independent  Director of the Board of
Directors,  (b) elect Melvin F. Lazar to serve as Lead Independent Director, (c)
adopt a Lead  Independent  Director  Charter  and (d)  adopt  amendments  to the
Bylaws, effective immediately, among other things, to add provisions relating to
the position of Lead Independent  Director.  The steps were taken as part of the
Company's   corporate   governance   initiatives   to  further   enhance   board
independence. The Lead Independent Director, among other things, coordinates the
activities  of the  independent  directors,  serves  as a  liaison  between  the
Chairman of the Board,  senior  management  of the  Company and the  independent
directors,  and presides at the executive sessions of the independent  directors
of the Company.

         The press  release  issued by the Company  announcing  the foregoing is
included as Exhibit 99.1 to this Current Report and is incorporated by reference
in its entirety into this Item 8.01.

         In accordance with General Instruction B.2 of Form 8-K, the information
in this Item 8.01 of this  Current  Report shall not be deemed to be "filed" for
purposes  of  Section  18 of the  Exchange  Act,  or  otherwise  subject  to the
liability of that section,  and shall not be  incorporated by reference into any
registration statement or other document filed under the Securities Act of 1933,
as amended,  or the  Exchange  Act,  except as shall be  expressly  set forth by
specific reference in such filing.

ITEM 9.01.       FINANCIAL STATEMENTS AND EXHIBITS.
                 ----------------------------------
   
(c) EXHIBITS.
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EXHIBIT NO.      DESCRIPTION
-----------      -----------

3.1              Enzo  Biochem,  Inc.  Bylaws,  as amended  and  restated  as of
                 October 31, 2005.

10.1             Enzo   Biochem,   Inc.   Summary   of   Non-Employee   Director
                 Compensation.

99.1             Press Release of Enzo Biochem, Inc., dated November 4, 2005.

99.2             Lead Independent Director Charter.






                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended,  the  registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.

                                      ENZO BIOCHEM, INC.


Date:  November 3, 2005               By: /s/ BARRY WEINER
                                          -------------------------------------
                                          Barry Weiner
                                          President and Chief Financial Officer






















                                  EXHIBIT INDEX
                                  -------------

EXHIBIT NO.      DESCRIPTION
-----------      -----------

3.1              Enzo  Biochem,  Inc.  Bylaws,  as amended  and  restated  as of
                 October 31, 2005.

10.1             Enzo   Biochem,   Inc.   Summary   of   Non-Employee   Director
                 Compensation.

99.1             Press Release of Enzo Biochem, Inc., dated November 4, 2005.

99.2             Lead Independent Director Charter.