UNITED STATES
                  SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C.  20549

                              FORM 13F

                        FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: 03/31/06

Check here if Amendment [  ]; Amendment Number:
This Amendment (Check only one.): [  ] is a restatement.
                                  [  ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:    PEOPLES BANK, NATIONAL ASSOCIATION
Address: 138 PUTNAM STREET

         MARIETTA, OH 45750

13F File Number:        28 - ________________________________

The institutional investment manager filing this report and the
person by whom it is signed hereby represent that the person
signing the report is authorized to submit it, that all
information contained herein is true, correct and complete, and
that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of
this form.


Person Signing this Report on Behalf of Reporting Manager:

Name:     DAVID T WESEL,
Title:    EXECUTIVE VICE PRESIDENT & PRESIDENT, PEOPLES FINANCIAL ADVISORS
Phone:    740-373-2932
Signature, Place, and Date of Signing:


/s/   David T. Wesel         Marietta, Oh      April 18, 2006
    ------------------     ----------------  ------------------
      DAVID T. WESEL           CITY, STATE          DATE



Report Type (Check only one.):

[ X ]  13F HOLDINGS REPORT.

[   ]  13F NOTICE.

[   ]  13F COMBINATION REPORT.





I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE
ACT OF 1934.



                          FORM 13F SUMMARY PAGE


Report Summary:

Number of Other Included Managers:              0

Form 13F Information Table Entry Total:       164

Form 13F Information Table Entry Total:  $153,776



List of Other Included Managers:

NONE







                                                                FORM 13F INFORMATION TABLE
                                                           VALUE   SHARES/  SH/ PUT/ INVSTMT    OTHER          VOTING AUTHORITY
        NAME OF ISSUER         TITLE OF CLASS     CUSIP   (x$1000) PRN AMT  PRN CALL DSCRETN   MANAGERS     SOLE    SHARED    NONE
------------------------------ ---------------- --------- -------- --- ---  --- ---- ------- ------------- ------- --------- ------
                                                                                                
AT&T INC                       COM              00206R102      386    14285 SH       SOLE                    14285
AT&T INC                       COM              00206R102       13      501 SH       OTHER                     501
ABBOTT LABORATORIES            COM              002824100      705    16620 SH       SOLE                    16620
ABBOTT LABORATORIES            COM              002824100       69     1630 SH       OTHER                    1630
AMERICAN INTL GROUP INC        COM              026874107      895    13546 SH       SOLE                    13546
AMERICAN INTL GROUP INC        COM              026874107       18      280 SH       OTHER                     280
BP AMOCO PLC SPONS ADR         COM              055622104     1439    20875 SH       SOLE                    19625              1250
BP AMOCO PLC SPONS ADR         COM              055622104      411     5968 SH       OTHER                    5968
BANK OF AMERICA CORP           COM              060505104     1970    43276 SH       SOLE                    41386              1890
BANK OF AMERICA CORP           COM              060505104       62     1374 SH       OTHER                    1374
BELLSOUTH CORP COMMON          COM              079860102      277     7996 SH       SOLE                     7996
BELLSOUTH CORP COMMON          COM              079860102       30      876 SH       OTHER                     876
CVS CORPORATION                COM              126650100      252     8465 SH       SOLE                     7080              1385
CAMCO FINANCIAL CORP           COM              132618109      532    37051 SH       SOLE                    37051
CHEVRON CORPORATION            COM              166764100     1555    26839 SH       SOLE                    26839
CHEVRON CORPORATION            COM              166764100      315     5450 SH       OTHER                    5450
CISCO SYSTEMS                  COM              17275R102      817    37730 SH       SOLE                    37730
CISCO SYSTEMS                  COM              17275R102       60     2805 SH       OTHER                    2805
COCA COLA CO COMMON            COM              191216100      229     5475 SH       SOLE                     5475
COCA COLA CO COMMON            COM              191216100       47     1140 SH       OTHER                    1140
COLGATE PALMOLIVE              COM              194162103      402     7055 SH       SOLE                     7055
COLGATE PALMOLIVE              COM              194162103       10      180 SH       OTHER                     180
DANAHER CORP                   COM              235851102      549     8640 SH       SOLE                     7100              1540
DANAHER CORP                   COM              235851102       40      640 SH       OTHER                     640
DELL INC                       COM              24702R101      196     6604 SH       SOLE                     6604
DELL INC                       COM              24702R101       24      830 SH       OTHER                     830
DOW JONES INDUSTRIAL TRUST SER COM              252787106      164     1480 SH       SOLE                     1480
DOW JONES INDUSTRIAL TRUST SER COM              252787106       52      473 SH       OTHER                     473
DOVER CORP.                    COM              260003108      223     4610 SH       SOLE                     4610
DOW CHEMCIAL CO                COM              260543103      671    16531 SH       SOLE                    16531
DOW CHEMCIAL CO                COM              260543103       12      300 SH       OTHER                     300
DUPONT EI DE NEMOURS & CO      COM              263534109      181     4300 SH       SOLE                     4300
DUPONT EI DE NEMOURS & CO      COM              263534109       61     1457 SH       OTHER                    1457
EMC CORPORATION                COM              268648102      441    32415 SH       SOLE                    32415
EMC CORPORATION                COM              268648102       12      900 SH       OTHER                     900
EXELON CORPORATION             COM              30161N101      363     6866 SH       SOLE                     6866
EXELON CORPORATION             COM              30161N101       32      620 SH       OTHER                     620
EXXON MOBIL CORPORATION        COM              30231G102     4045    66467 SH       SOLE                    65257              1210
EXXON MOBIL CORPORATION        COM              30231G102      224     3696 SH       OTHER                    3696
FIRST FEDERAL DOVER FINANCIAL  COM              30243C107      318    15150 SH       DEFINED                                   15150
FISERV                         COM              337738108      485    11400 SH       SOLE                    11400
GANNETT CO INC COMMON          COM              364730101       52      881 SH       SOLE                      506               375
GANNETT CO INC COMMON          COM              364730101      837    13976 SH       OTHER                   13976
GENERAL ELECTRIC CO COMMON     COM              369604103     3011    86597 SH       SOLE                    86597
GENERAL ELECTRIC CO COMMON     COM              369604103      368    10581 SH       DEFINED                                   10581
GENERAL ELECTRIC CO COMMON     COM              369604103      205     5901 SH       OTHER                    5901
GOLDMAN SACHS GROUP            COM              38141G104      579     3695 SH       SOLE                     3695
HEARTLAND BANCORP              COM              421962101     3856   113102 SH       DEFINED                                  113102
HOME DEPOT                     COM              437076102      534    12642 SH       SOLE                    10712              1930
HUNTINGTON BANCSHARES          COM              446150104      942    39041 SH       SOLE                     1291             37750
HUNTINGTON BANCSHARES          COM              446150104       48     1994 SH       OTHER                    1994
ITT INDUSTRIES INC             COM              450911102      487     8675 SH       SOLE                     8675
ITT INDUSTRIES INC             COM              450911102       22      400 SH       OTHER                     400
INTEL CORP                     COM              458140100      894    45986 SH       SOLE                    45986
INTEL CORP                     COM              458140100       25     1300 SH       OTHER                    1300
INTERNATIONAL BUSINESS MACH CO COM              459200101      128     1556 SH       SOLE                     1556
INTERNATIONAL BUSINESS MACH CO COM              459200101       82     1000 SH       OTHER                    1000
ISHARES COMEX GOLD             COM              464285105     1075    18475 SH       SOLE                    18475
ISHARES COMEX GOLD             COM              464285105       66     1150 SH       OTHER                    1150
I SHARES MSCI JAPAN INDEX FD   COM              464286848      548    38115 SH       SOLE                    38115
I SHARES MSCI JAPAN INDEX FD   COM              464286848       46     3200 SH       OTHER                    1500              1700
ISHARES DJ SELECT DIV          COM              464287168     1795    28644 SH       SOLE                    28644
I SHARES S & P 500 INDEX       COM              464287200     2041    15714 SH       SOLE                    15714
ISHARES MSCI EMERGING MARKET   COM              464287234     1318    13314 SH       SOLE                    13314
ISHARES MSCI EMERGING MARKET   COM              464287234       61      625 SH       OTHER                     350               275
I SHARES S&P 500 BARRA GROWTH  COM              464287309     2959    48594 SH       SOLE                    48594
I SHARES S&P 500 BARRA GROWTH  COM              464287309      229     3770 SH       OTHER                    2370              1400
ISHARES GOLDMAN SACHS NATURAL  COM              464287374      503     5250 SH       SOLE                     5250
ISHARES GOLDMAN SACHS NATURAL  COM              464287374       16      175 SH       OTHER                     175
I SHARES S&P 500 BARRA VALUE   COM              464287408     1225    17828 SH       SOLE                    17828
I SHARES S&P 500 BARRA VALUE   COM              464287408      148     2160 SH       OTHER                    2160
ISHARES MSCI EAFE INDEX FOREIG COM              464287465    11461   176541 SH       SOLE                   176541
ISHARES MSCI EAFE INDEX FOREIG COM              464287465     1048    16154 SH       OTHER                   16154
ISHARES RUSSELL MIDCAP GROWTH  COM              464287481      885     8736 SH       SOLE                     8736
ISHARES RUSSELL MIDCAP GROWTH  COM              464287481      195     1925 SH       OTHER                    1925
ISHARES RUSSELL MIDCAP         COM              464287499      681     7198 SH       SOLE                     7198
ISHARES RUSSELL MIDCAP         COM              464287499      175     1850 SH       OTHER                    1850
I SHARES S&P 400 MIDCAP        COM              464287507     4013    50625 SH       SOLE                    50625
I SHARES S&P 400 MIDCAP        COM              464287507      543     6860 SH       OTHER                    6860
I SHARES RUSSELL 1000 VALUE    COM              464287598     3839    52513 SH       SOLE                    52513
I SHARES RUSSELL 1000 VALUE    COM              464287598      176     2420 SH       OTHER                    1715               705
I SHARES S&P 400 MIDCAP GROWTH COM              464287606      803     9980 SH       SOLE                     9980
I SHARES S&P 400 MIDCAP GROWTH COM              464287606       10      134 SH       OTHER                     134
I SHARES RUSSELL 1000 GROWTH   COM              464287614     3436    65152 SH       SOLE                    65152
I SHARES RUSSELL 1000 GROWTH   COM              464287614      236     4490 SH       OTHER                    3515               975
I SHARES RUSSELL 1000          COM              464287622     3520    49805 SH       SOLE                    49805
I SHARES RUSSELL 1000          COM              464287622      855    12106 SH       OTHER                   12106
I SHARES RUSSELL 2000          COM              464287655      587     7729 SH       SOLE                     7729
I SHARES RUSSELL 2000          COM              464287655       25      340 SH       OTHER                                       340
I SHARES S&P 400 MIDCAP VALUE  COM              464287705      822    10722 SH       SOLE                    10722
ISHARES DJ US TECHNOLOGY       COM              464287721      443     8483 SH       SOLE                     8483
ISHARES DJ US TECHNOLOGY       COM              464287721       16      308 SH       OTHER                     308
ISHARES DJ US REAL ESTATE      COM              464287739     1180    16068 SH       SOLE                    16068
ISHARES DJ US REAL ESTATE      COM              464287739       53      730 SH       OTHER                     190               540
ISHARES DJ US ENERGY SECTOR    COM              464287796      206     2240 SH       SOLE                     2240
ISHARES DJ US ENERGY SECTOR    COM              464287796        5       56 SH       OTHER                      56
I SHARES S&P 600 SMALL CAP     COM              464287804     1695    25985 SH       SOLE                    25985
I SHARES S&P 600 SMALL CAP     COM              464287804       19      300 SH       OTHER                     300
I SHARES S&P 600 SMALL CAP VAL COM              464287879      259     3568 SH       SOLE                     3568
I SHARES S&P 600 SMALL CAP GRO COM              464287887      457     3535 SH       SOLE                     3535
ISHARES KLD INDEX              COM              464288802      442     8040 SH       SOLE                     8040
J P MORGAN CHASE & CO          COM              46625H100      152     3657 SH       SOLE                     3657
J P MORGAN CHASE & CO          COM              46625H100       75     1813 SH       OTHER                    1400               413
JOHNSON & JOHNSON              COM              478160104      927    15654 SH       SOLE                    15654
JOHNSON & JOHNSON              COM              478160104       35      600 SH       OTHER                     600
ELI LILLY                      COM              532457108      192     3472 SH       SOLE                     3472
ELI LILLY                      COM              532457108       38      700 SH       OTHER                     700
LOWES COMPANY                  COM              548661107      324     5040 SH       SOLE                     5040
LOWES COMPANY                  COM              548661107       17      275 SH       OTHER                     275
MASSEY ENERGY CO               COM              576206106      228     6330 SH       SOLE                     6330
MEDTRONIC INC                  COM              585055106      497     9795 SH       SOLE                     9795
MERRILL LYNCH                  COM              590188108      263     3345 SH       SOLE                     3345
MERRILL LYNCH                  COM              590188108       11      150 SH       OTHER                     150
MICROSOFT                      COM              594918104      938    34495 SH       SOLE                    34495
MICROSOFT                      COM              594918104       69     2540 SH       OTHER                    2540
NIKE CLASS B                   COM              654106103      582     6840 SH       SOLE                     5915               925
NIKE CLASS B                   COM              654106103        9      115 SH       OTHER                     115
ORACLE CORPORATION             COM              68389X105      158    11577 SH       SOLE                    11577
ORACLE CORPORATION             COM              68389X105        6      500 SH       OTHER                     500
PEABODY ENERGY CORP            COM              704549104      282     5600 SH       SOLE                     5600
PEOPLES BANCORP INC.           COM              709789101     9716   323879 SH       SOLE                   272864   694977
PEOPLES BANCORP INC.           COM              709789101                   SH       DEFINED
PEOPLES BANCORP INC.           COM              709789101    24786   826198 SH       OTHER                  131221    51015
PEPSICO                        COM              713448108      760    13167 SH       SOLE                    13167
PEPSICO                        COM              713448108       41      712 SH       OTHER                     712
PFIZER INC COMMON              COM              717081103      194     7804 SH       SOLE                     7804
PFIZER INC COMMON              COM              717081103       23      932 SH       OTHER                     932
PRICE GROUP                    COM              74144T108      264     3385 SH       SOLE                     3385
PROCTER & GAMBLE COMPANY COMMO COM              742718109     1444    25066 SH       SOLE                    25066
PROCTER & GAMBLE COMPANY COMMO COM              742718109       65     1140 SH       OTHER                    1140
ROCKWELL AUTOMATION INC        COM              773903109      186     2600 SH       SOLE                     2600
ROCKWELL AUTOMATION INC        COM              773903109       35      500 SH       OTHER                     500
ROCKY SHOES & BOOTS INC        COM              774830103     5052   191729 SH       OTHER                   23005            168724
RYDEX S&P 500 EQUAL-WEIGHT EFT COM              78355W106     7545    42777 SH       SOLE                    42777
RYDEX S&P 500 EQUAL-WEIGHT EFT COM              78355W106      996     5649 SH       OTHER                    5649
S & P 500 DEPOSITARY RECEIPT S COM              78462F103     3976    30625 SH       SOLE                    30625
S & P 500 DEPOSITARY RECEIPT S COM              78462F103      122      940 SH       OTHER                     940
SIMON PPTY GROUP INC NEW       COM              828806109      425     5062 SH       SOLE                     5062
SIMON PPTY GROUP INC NEW       COM              828806109       42      504 SH       OTHER                     504
STAPLES INC                    COM              855030102      314    12342 SH       SOLE                    12342
TARGET CORPORATION             COM              87612E106      865    16632 SH       SOLE                    15737               895
TARGET CORPORATION             COM              87612E106       24      480 SH       OTHER                     480
3M COMPANY                     COM              88579Y101      576     7611 SH       SOLE                     7611
3M COMPANY                     COM              88579Y101       15      200 SH       OTHER                     200
US BANCORP DEL                 COM              902973304      318    10455 SH       SOLE                    10455
UNITED BANKSHARES INC          COM              909907107     1251    32700 SH       SOLE                    32700
UNITED TECHNOLOGIES INC        COM              913017109     1282    22130 SH       SOLE                    20570              1560
UNITED TECHNOLOGIES INC        COM              913017109       22      396 SH       OTHER                     396
UNITEDHEALTH GROUP INC         COM              91324P102      595    10660 SH       SOLE                    10660
UNITEDHEALTH GROUP INC         COM              91324P102       15      275 SH       OTHER                     275
VERIZON COMMUNICATIONS         COM              92343V104      402    11807 SH       SOLE                    11807
VERIZON COMMUNICATIONS         COM              92343V104       23      676 SH       OTHER                     676
WACHOVIA CORP                  COM              929903102      433     7727 SH       SOLE                     7727
WAL MART STORES INC            COM              931142103      205     4359 SH       SOLE                     3359              1000
WALGREEN CO COMMON             COM              931422109      969    22490 SH       SOLE                    22490
WALGREEN CO COMMON             COM              931422109       68     1589 SH       OTHER                    1589
WELLS FARGO AND COMPANY        COM              949746101      918    14379 SH       SOLE                    13084              1295
WESBANCO                       COM              950810101      281     8591 SH       SOLE                     8591
WESBANCO                       COM              950810101       97     2985 SH       OTHER                    1425              1560
WYETH COMM                     COM              983024100     3068    63240 SH       SOLE                    63240
WYETH COMM                     COM              983024100      145     3000 SH       OTHER                    3000
ACCENTURE LTD CLASS A          COM              G1150G111      501    16675 SH       SOLE                    14105              2570
ACCENTURE LTD CLASS A          COM              G1150G111       15      500 SH       OTHER                     500
TRANSOCEAN SEDCO FOREX INC     COM              G90078109      289     3605 SH       SOLE                     3605