Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MPM BioVentures IV QP LP
  2. Issuer Name and Ticker or Trading Symbol
CHIASMA, INC [CHMA]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O MPM CAPITAL, 450 KENDALL STREET
3. Date of Earliest Transaction (Month/Day/Year)
07/21/2015
(Street)

CAMBRIDGE, MA 02142
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/21/2015   C   10,426 (1) A (2) 10,426 I See Footnote (3)
Common Stock 07/21/2015   C   2,488,171 (4) A (2) 2,498,597 I See Footnote (5)
Common Stock 07/21/2015   C   1,759,381 (6) A (2) 4,257,978 I See Footnote (7)
Common Stock 07/21/2015   C   1,423,566 (8) A (2) 5,681,544 I See Footnote (9)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series B-1' Preferred Stock (2) 07/21/2015   C     95,225 (1)   (2)   (2) Common Stock 10,426 (1) (2) 0 I See Footnote (1)
Series C' Preferred Stock (2) 07/21/2015   C     22,721,988 (4)   (2)   (2) Common Stock 2,488,171 (4) (2) 0 I See Footnote (4)
Series D' Preferred Stock (2) 07/21/2015   C     16,066,669 (6)   (2)   (2) Common Stock 1,759,381 (6) (2) 0 I See Footnote (6)
Series E Preferred Stock (2) 07/21/2015   C     13,000,000 (8)   (2)   (2) Common Stock 1,423,566 (8) (2) 0 I See Footnote (8)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MPM BioVentures IV QP LP
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
EVNIN LUKE
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
Scopa James Paul
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
KAILIAN VAUGHN M
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
MPM Asset Management Investors BV4 LLC
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
MPM Bio IV NVS Strategic Fund LP
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
MPM BioVentures IV GmbH & Co. Beteiligungs KG
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
MPM BioVentures IV GP LLC
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    
MPM BioVentures IV LLC
C/O MPM CAPITAL
450 KENDALL STREET
CAMBRIDGE, MA 02142
    X    

Signatures

 By Luke Evnin, member of MPM BioVenture IV LLC, the managing member of MPM BioVentures IV GP LLC, the general partner of MPM BioVentures IV-QP, L.P. /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 /s/ James Paul Scopa   07/21/2015
**Signature of Reporting Person Date

 /s/ Vaughn M. Kailian   07/21/2015
**Signature of Reporting Person Date

 By Luke Evnin, member of MPM BioVenture IV LLC, the manager of MPM Asset Management Investors BV4 LLC /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 By Luke Evnin, member of MPM BioVenture IV LLC, the managing member of MPM BioVentures IV GP LLC, the general partner of MPM Bio IV NVS Strategic Fund, L.P. /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 By Luke Evnin, member of MPM BioVenture IV LLC, the managing member of MPM BioVentures IV GP LLC, the managing limited partner of MPM BioVentures IV GmbH & Co. Beteiligungs KG /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 By Luke Evnin, member of MPM BioVentures IV LLC, the managing member of MPM BioVentures IV GP LLC /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

 By Luke Evnin, member of MPM BioVenture IV LLC /s/ Luke Evnin   07/21/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The shares, on a common stock equivalent basis, were converted as follows: 9,773 by MPM BioVentures IV-QP, L.P. ("BV IV QP"), 376 by MPM BioVentures IV GmbH & Co. Beteiligungs KG ("BV IV KG") and 277 by MPM Asset Management Investors BV4 LLC ("AM BV4"). MPM BioVentures IV GP LLC ("BV GP LLC") and MPM BioVentures IV LLC ("BV LLC") are the direct and indirect general partners of BV IV QP and BV IV KG and BV LLC is the manager of AM BV4. Ansbert Gadicke, Luke Evnin, Vaughn M. Kailian, James Paul Scopa and Todd Foley are the members of BV LLC. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(2) The shares of Series B-1' Preferred Stock, Series C' Preferred Stock, Series D' Preferred Stock and Series E Preferred Stock converted into 0.109505 of a share of the Issuer's Common Stock immediately prior to the closing of the Issuer's initial public offering without payment of further consideration. The shares had no expiration date.
(3) The shares are held as follows: 9,773 by BV IV QP, 376 by BV IV KG and 277 by AM BV4. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(4) The shares, on a common stock equivalent basis, were converted as follows: 1,479,910 by BV IV QP, 57,016 by BV IV KG, 42,083 by AM BV4 and 909,162 by MPM Bio IV NVS Strategic Fund, L.P. ("BV IV SF"). BV GP LLC and BV LLC are the direct and indirect general partners of BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(5) The shares are held as follows: 1,489,683 by BV IV QP, 57,392 by BV IV KG, 42,360 by AM BV4 and 909,162 by BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(6) The shares, on a common stock equivalent basis, were converted as follows: 1,539,486 by BV IV QP, 59,313 by BV IV KG, 43,776 by AM BV4 and 116,806 by BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(7) The shares are held as follows: 3,029,169 by BV IV QP, 116,705 by BV IV KG, 86,136 by AM BV4 and 1,025,968 by BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(8) The shares, on a common stock equivalent basis, were converted as follows: 939,089 by BV IV QP, 36,179 by BV IV KG, 26,704 by AM BV4 and 421,594 by BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.
(9) The shares are held as follows: 3,968,258 by BV IV QP, 152,884 by BV IV KG, 112,840 by AM BV4 and 1,447,562 by BV IV SF. Each Reporting Person disclaims beneficial ownership of the securities except to the extent of his or its respective pecuniary interest therein.

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