Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Mulligan Valerie
 2. Date of Event Requiring Statement (Month/Day/Year)
10/07/2005		 3. Issuer Name and Ticker or Trading Symbol
NEOSE TECHNOLOGIES INC [NTEC]
(Last)
(First)
(Middle)
102 WITMER ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Vice President
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

HORSHAM, PA 19044		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 5,689
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Incentive Stock Option (right to buy)   (1) 02/12/2013 Common Stock 7,782 $ 7.45 D  
Incentive Stock Option (right to buy)   (2) 08/02/2012 Common Stock 5,775 $ 7.91 D  
Incentive Stock Option (right to buy)   (3) 02/03/2014 Common Stock 9,162 $ 11.68 D  
Incentive Stock Option (right to buy)   (4) 12/02/2008 Common Stock 5,000 $ 13.5 D  
Incentive Stock Option (right to buy)   (4) 12/19/2007 Common Stock 5,000 $ 13.625 D  
Incentive Stock Option (right to buy)   (4) 12/07/2009 Common Stock 4,500 $ 14 D  
Incentive Stock Option (right to buy)   (4) 11/20/2006 Common Stock 7,500 $ 14.625 D  
Incentive Stock Option (right to buy)   (4) 12/02/2006 Common Stock 1,000 $ 15.125 D  
Incentive Stock Option (right to buy)   (4) 12/21/2010 Common Stock 5,000 $ 28.75 D  
Incentive Stock Option (right to buy)   (5) 12/13/2011 Common Stock 5,959 $ 29 D  
Non-Qualified Stock Option (right to buy)   (6) 08/05/2015 Common Stock 8,500 $ 2.58 D  
Non-Qualified Stock Option (right to buy)   (7) 02/24/2015 Common Stock 10,000 $ 4.22 D  
Non-Qualified Stock Option (right to buy)   (4) 02/12/2013 Common Stock 2,218 $ 7.45 D  
Non-Qualified Stock Option (right to buy)   (4) 08/02/2012 Common Stock 1,725 $ 7.91 D  
Non-Qualified Stock Option (right to buy)   (4) 02/03/2014 Common Stock 838 $ 11.68 D  
Non-Qualified Stock Option (right to buy)   (4) 12/13/2011 Common Stock 541 $ 29 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Mulligan Valerie
102 WITMER ROAD
HORSHAM, PA 19044		       Vice President  

Signatures

By: Scott R. Jones for Valerie Mulligan 10/17/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) 2,782 options are currently exercisable. Of the remaining 5,000 options, 2,500 options will become exercisable on each of Feburary 12, 2006 and 2007.
(2) 3,900 options are currently exercisable. The remaining 1,875 options will become exercisable on August 2, 2006.
(3) 1,662 options are currently exercisable. Of the remaining 7,500 options, 2,500 options will become exercisable on each of Feburary 3, 2006, 2007 and 2008.
(4) All options are currently exercisable.
(5) 4,334 options are currently exercisable. The remaining 1,625 options will become exercisable on December 13, 2005.
(6) None of the options are currently exercisable. 4,250 options will become exercisable on each of November 1, 2005 and May 1, 2006.
(7) None of the options are currently exercisable. 2,500 options will become exercisable on each of February 24, 2006, 2007, 2008 and 2009.

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