Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Isabelle Warren John
  2. Issuer Name and Ticker or Trading Symbol
SENESCO TECHNOLOGIES INC [SNT]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
303 GEORGE STREET, SUITE 420
3. Date of Earliest Transaction (Month/Day/Year)
02/19/2010
(Street)

NEW BRUNSWICK, NJ 08901
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/19/2010   P   16,745 A $ 0 (1) 18,967 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Common Stock Warrant $ 1.01 02/19/2010   P   9,691   02/19/2010 06/30/2012 Common Stock 9,691 $ 0 (1) 13,719 D  
Common Stock Warrant $ 1.01 02/19/2010   P   16,152   02/19/2010 12/20/2012 Common Stock 16,152 $ 0 (1) 29,871 D  
Common Stock Warrant $ 1.01 02/19/2010   P   10,768   02/19/2010 06/30/2013 Common Stock 10,768 $ 0 (1) 40,639 D  
Common Stock Warrant $ 0.83 02/19/2010   P   16,152   02/19/2010 12/20/2012 Common Stock 16,152 $ 0 (1) 56,791 D  
Common Stock Warrant $ 0.83 02/19/2010   P   10,768   02/19/2010 06/30/2013 Common Stock 10,768 $ 0 (1) 67,559 D  
Convertible Debenture Due 12/31/2010 $ 0.22 (2) 02/19/2010   P   $ 64,607   02/19/2010 12/31/2010 Common Stock 287,626 $ 0 (1) 287,626 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Isabelle Warren John
303 GEORGE STREET
SUITE 420
NEW BRUNSWICK, NJ 08901
  X      

Signatures

 Warren J. Isabelle   02/23/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Mr. Isabelle entered into agreements to purchase an aggregate of 16,745 shares of common stock, 63,531 common stock warrants and $64,607 of convertible debentures. The total purchase price was $11,500, which was not allocated among the various components.
(2) The conversion rate used is the rate that the convertible debentures may convert at as of February 19, 2010. However, the conversion rate may change as the convertible debentures convert at a floating conversion rate equal to the lower of $0.83, subject to adjustment, or 80% of the lowest daily VWAP for the five day period immediately preceding the conversion date.

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