SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G
(Amendment No. 2)

Under the Securities Exchange Act of 1934 

Replidyne, Inc.
(Name of Issuer)

Common Stock, $0.001 par value
(Title of Class of Securities)

76028W107
(CUSIP Number)

April 30, 2007
(Date of Event Which Requires Filing of this Statement)  
 
Check the following box to designate the rule pursuant to which the Schedule is filed:
 
o 
Rule 13d-1(b)
x
Rule 13d-1(c)
o 
Rule 13d-1(d)
 
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
 
CUSIP No. 76028W107
 
 
1.
Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
D. E. Shaw Meniscus Portfolios, L.L.C.
51-0481096
     
 
2.
Check the Appropriate Box if a Member of a Group (See Instructions)
   
(a)
o 
   
(b)
o 
       
 
3.
SEC Use Only
     
 
4.
Citizenship or Place of Organization
Delaware
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5.
Sole Voting Power
 
 
-0-
     
     
6.
Shared Voting Power
-0-
         
     
7.
Sole Dispositive Power
-0-
         
     
8.
Shared Dispositive Power
-0-
         
 
9.
Aggregate Amount Beneficially Owned by Each Reporting Person
-0-
     
 
10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)        o
 
     
 
11.
Percent of Class Represented by Amount in Row (9)
0.0%
     
 
12.
Type of Reporting Person (See Instructions)
OO
 

CUSIP No. 76028W107
  
   
 
1.
Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
D. E. Shaw Composite Portfolios, L.L.C.
13-4152438
  
       
 
2.
Check the Appropriate Box if a Member of a Group (See Instructions)
 
   
(a)
o 
  
   
(b)
o 
  
         
 
3.
SEC Use Only
 
       
 
4.
Citizenship or Place of Organization
Delaware
  
       
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5.
Sole Voting Power
 
 
-0-
  
       
     
6.
Shared Voting Power
2,215,820
  
           
     
7.
Sole Dispositive Power
-0-
  
           
     
8.
Shared Dispositive Power
2,215,820
  
           
 
9.
Aggregate Amount Beneficially Owned by Each Reporting Person
2,215,820
  
       
 
10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)         o 
 
  
       
 
11.
Percent of Class Represented by Amount in Row (9)
8.2%
  
       
 
12.
Type of Reporting Person (See Instructions)
OO
  

 
CUSIP No. 76028W107
 
 
1.
Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
D. E. Shaw & Co., L.L.C.
13-3799946
     
 
2.
Check the Appropriate Box if a Member of a Group (See Instructions)
   
(a)
o 
   
(b)
o 
       
 
3.
SEC Use Only
     
 
4.
Citizenship or Place of Organization
Delaware
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5.
Sole Voting Power
 
 
-0-
     
     
6.
Shared Voting Power
2,215,820
         
     
7.
Sole Dispositive Power
-0-
         
     
8.
Shared Dispositive Power
2,215,820
         
 
9.
Aggregate Amount Beneficially Owned by Each Reporting Person
2,215,820
     
 
10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)         o 
 
     
 
11.
Percent of Class Represented by Amount in Row (9)
8.2%
     
 
12.
Type of Reporting Person (See Instructions)
OO
 

CUSIP No. 76028W107
  
   
 
1.
Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
D. E. Shaw & Co., L.P.
13-3695715
  
       
 
2.
Check the Appropriate Box if a Member of a Group (See Instructions)
 
   
(a)
o 
  
   
(b)
o 
  
         
 
3.
SEC Use Only
 
       
 
4.
Citizenship or Place of Organization
Delaware
  
       
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5.
Sole Voting Power
 
 
-0-
  
       
     
6.
Shared Voting Power
2,313,722
  
           
     
7.
Sole Dispositive Power
-0-
  
           
     
8.
Shared Dispositive Power
2,313,722
  
           
 
9.
Aggregate Amount Beneficially Owned by Each Reporting Person
2,313,722
  
       
 
10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)         o 
 
  
       
 
11.
Percent of Class Represented by Amount in Row (9)
8.6%
  
       
 
12.
Type of Reporting Person (See Instructions)
IA, PN
  
 
 
CUSIP No. 76028W107
  
   
 
1.
Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
David E. Shaw
  
       
 
2.
Check the Appropriate Box if a Member of a Group (See Instructions)
 
   
(a)
o 
  
   
(b)
o 
  
         
 
3.
SEC Use Only
 
       
 
4.
Citizenship or Place of Organization
United States
  
       
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5.
Sole Voting Power
 
 
-0-
  
       
     
6.
Shared Voting Power
2,313,722
  
           
     
7.
Sole Dispositive Power
-0-
  
           
     
8.
Shared Dispositive Power
2,313,722
  
           
 
9.
Aggregate Amount Beneficially Owned by Each Reporting Person
2,313,722
  
       
 
10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)         o 
 
  
       
 
11.
Percent of Class Represented by Amount in Row (9)
8.6%
  
       
 
12.
Type of Reporting Person (See Instructions)
IN
  
 
 
Item 1.
 
(a) 
Name of Issuer
   
Replidyne, Inc.
 
 
  
 
(b) 
Address of Issuer's Principal Executive Offices
   
1450 Infinite Drive
Louisville, CO 80027
 
Item 2.
 
(a) 
Name of Person Filing
   
D. E. Shaw Meniscus Portfolios, L.L.C.
D. E. Shaw Composite Portfolios, L.L.C.
D. E. Shaw & Co., L.L.C.
D. E. Shaw & Co., L.P.
David E. Shaw
     
 
(b) 
Address of Principal Business Office or, if none, Residence
   
The business address for each reporting person is:
120 W. 45th Street, Tower 45, 39th Floor
New York, NY 10036
     
 
(c) 
Citizenship
   
D. E. Shaw Meniscus Portfolios, L.L.C. is a limited liability company organized under the laws of the state of Delaware.
D. E. Shaw Composite Portfolios, L.L.C. is a limited liability company organized under the laws of the state of Delaware.
D. E. Shaw & Co., L.L.C. is a limited liability company organized under the laws of the state of Delaware.
D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware.
David E. Shaw is a citizen of the United States of America.
     
 
(d) 
Title of Class of Securities
   
Common Stock, $0.001 par value
     
 
(e) 
CUSIP Number
   
76028W107
 
Item 3. If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:
 
Not applicable
 
Item 4. Ownership 
  
   
As of May 3, 2007:
  
   
(a) Amount beneficially owned:
  
   
D. E. Shaw Meniscus Portfolios, L.L.C.:
-0- shares
   
D. E. Shaw Composite Portfolios, L.L.C.:
2,215,820 shares
   
D. E. Shaw & Co., L.L.C.:
2,215,820 shares
This is composed of 2,215,820 shares in the name of
D. E. Shaw Composite Portfolios, L.L.C.
   
D. E. Shaw & Co., L.P.:
2,313,722 shares
This is composed of (i) 2,215,820 shares in the name of D. E. Shaw Composite Portfolios, L.L.C. and (ii) 97,902 shares in the name of D. E. Shaw Valence Portfolios, L.L.C.
   
 
 
David E. Shaw: 
2,313,722 shares
This is composed of (i) 2,215,820 shares in the name of D. E. Shaw Composite Portfolios, L.L.C. and (ii) 97,902 shares in the name of D. E. Shaw Valence Portfolios, L.L.C.
   
(b) Percent of class: 
 
D. E. Shaw Meniscus Portfolios, L.L.C.:
0.0%
D. E. Shaw Composite Portfolios, L.L.C.:
8.2%
D. E. Shaw & Co., L.L.C.:
8.2%
D. E. Shaw & Co., L.P.:
8.6%
David E. Shaw: 
8.6%
     
(c) Number of shares to which the person has: 
  
(i) 
Sole power to vote or to direct the vote: 
  
 
D. E. Shaw Meniscus Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw Composite Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw & Co., L.L.C.: 
-0- shares 
 
D. E. Shaw & Co., L.P.: 
-0- shares 
 
David E. Shaw: 
-0- shares 
     
(ii) 
Shared power to vote or to direct the vote: 
  
 
D. E. Shaw Meniscus Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw Composite Portfolios, L.L.C.:
2,215,820 shares
 
D. E. Shaw & Co., L.L.C.: 
2,215,820 shares
 
D. E. Shaw & Co., L.P.: 
2,313,722 shares
 
David E. Shaw: 
2,313,722 shares
     
(iii) 
Sole power to dispose or to direct the disposition of: 
  
 
D. E. Shaw Meniscus Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw Composite Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw & Co., L.L.C.: 
-0- shares 
 
D. E. Shaw & Co., L.P.: 
-0- shares 
 
David E. Shaw: 
-0- shares 
     
(iv) 
Shared power to dispose or to direct the disposition of: 
  
 
D. E. Shaw Meniscus Portfolios, L.L.C.:
-0- shares 
 
D. E. Shaw Composite Portfolios, L.L.C.:
2,215,820 shares
 
D. E. Shaw & Co., L.L.C.: 
2,215,820 shares
 
D. E. Shaw & Co., L.P.: 
2,313,722 shares
 
David E. Shaw: 
2,313,722 shares

David E. Shaw does not own any shares directly. By virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Composite Portfolios, L.L.C. and the managing member and investment adviser of D. E. Shaw Valence Portfolios, L.L.C., and by virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the managing member of D. E. Shaw Composite Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 2,313,722 shares as described above constituting 8.6% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 2,313,722 shares.
 
Item 5.
Ownership of Five Percent or Less of a Class
 
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following x
 
As of the date hereof, D. E. Shaw Meniscus Portfolios, L.L.C. has ceased to be the beneficial owner of more than 5 percent of the class of securities.
  
     
     
 
 
 
Item 6.
Ownership of More than Five Percent on Behalf of Another Person.
 
Not Applicable
  
     
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
 
Not Applicable
  

Item 8.
Identification and Classification of Members of the Group
 
Not Applicable
  
     
Item 9.
Notice of Dissolution of Group
 
Not Applicable
  
     
Item 10.
Certification
 
By signing below, each of D. E. Shaw Meniscus Portfolios, L.L.C., D. E. Shaw Composite Portfolios, L.L.C., D. E. Shaw & Co., L.L.C., D. E. Shaw & Co., L.P., and David E. Shaw certify that, to the best of such reporting person’s knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect.
 
 
SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. Powers of Attorney, dated February 24, 2004, granted by David E. Shaw in favor of Anne Dinning, are attached hereto.

Dated: May 10, 2007
 
 
D. E. Shaw Meniscus Portfolios, L.L.C.
 
By:   
D. E. Shaw & Co., L.L.C., as
managing member
 
 
 
 
 
 
 
 
 
By:   
/s/ Anne Dinning
Anne Dinning
Managing Director
 
 
D. E. Shaw Composite Porfolios, L.L.C.
 
By:   
D. E. Shaw & Co., L.L.C., as
managing member
 
 
 
 
 
 
 
 
 
By:   
/s/ Anne Dinning
Anne Dinning
Managing Director
 
     
  D. E. Shaw & Co., L.L.C.
 
 		  
 		  
 
  By:    /s/ Anne Dinning
 
Anne Dinning
Managing Director
 
     
  D. E. Shaw & Co., L.P.
 
 		  
 		  
 
  By:    /s/ Anne Dinning
 
Anne Dinning
Managing Director
 
     
  David E. Shaw
 
 		  
 		  
 
  By:    /s/ Anne Dinning
 
Anne Dinning
Attorney-in-Fact for David E. Shaw