The collaboration pairs the Genialis Supermodel with Inventia Life Science’s RASTRUM 3D cell model platform to test therapeutic hypotheses in models that mirror the tumor biology of specific patient groups

Genialis, the therapeutic intelligence company, and Inventia Life Science today announced a collaboration to improve how new treatments for pancreatic cancer are tested and matched to the patients most likely to benefit. The companies will combine Genialis' AI-powered patient insights with Inventia's RASTRUM 3D cell model platform to build human-relevant models of pancreatic ductal adenocarcinoma (PDAC) that correspond to the tumor biology of identifiable patient populations. Initial results from this collaboration will be presented this week at the Pancreatic Cancer Action Network (PanCAN)’s 2026 Scientific Summit in San Diego.

Recent advances in targeted therapies for pancreatic cancer have brought renewed attention to PDAC and underscored the need for better strategies to identify which patients are most likely to benefit from new treatments. Inventia’s RASTRUM platform prints reproducible 3D pancreatic cancer models in which tumor and stromal components can be controlled and perturbed independently. Genialis characterizes those models with the Genialis™ Supermodel — a large molecular model trained on a proprietary harmonized and curated transcriptomics dataset— and connects them to molecular states observed in the clinic. The collaboration also draws on data generated through Genialis’ long-standing collaboration with the Pancreatic Cancer Action Network (PanCAN).

In the study being presented on Friday, September 25, Genialis identified PDAC patients with poor prognosis based on the composition and activity of the tumor microenvironment across 644 pancreatic cancer patient tumors taken from the PanCAN SPARK “Know Your Tumor” cohort. Genialis then mapped those patient profiles to tumor-fibroblast co-culture models generated on RASTRUM, allowing researchers to investigate the biology associated with poor outcomes and identify potential therapeutic strategies. This gives drug developers a way to test new approaches in models that reflect the biology of the patients they are intended to treat.

“This collaboration closes an important gap in drug discovery by connecting what we learn from patients with what we can test in the lab,” said Cameron Ferris, PhD, Chief Executive Officer and Co-Founder of Inventia Life Science. “Genialis can identify clinically meaningful biological states in real tumors, while RASTRUM allows us to model and perturb those states at scale. Together, that creates a powerful way to generate and test therapeutic hypotheses that are grounded in the biology of the patients we ultimately want to treat.”

The design closes a loop that translational programs usually leave open: hypotheses are derived from patient data, tested experimentally in human-relevant systems, and returned to the clinical population to determine where they are most likely to apply.

“Our pharma partners need to make critical decisions about which patients to enroll and which combinations to pursue, yet historically, whether a preclinical result would translate to patients often wasn’t clear until Phase 2,” said Rafael Rosengarten, PhD, Chief Executive Officer and Co-Founder of Genialis. “Inventia gives us a model where we can test those hypotheses experimentally, while the Supermodel helps identify the patients most likely to benefit.”

For more information, please visit www.genialis.com

About Genialis

Genialis provides therapeutic intelligence with its Supermodel of cancer biology. We develop and validate clinically actionable AI models informed by the world’s most ethnographically diverse cancer data sets to predict patient responses and guide treatment decisions for targeted inhibitors, immunotherapies, and other emerging therapeutic classes. Genialis is trusted by pharma and diagnostics partners, and together, we are transforming medicine through data. The company is headquartered in Houston, Boston and Ljubljana.

About Inventia Life Science

Inventia Life Science develops advanced 3D cell culture solutions that help researchers generate reproducible, biologically relevant in vitro models at scale. Built around the RASTRUM platform, Inventia combines precision drop-on-demand bioprinting, tunable synthetic matrices, workflow-driven software, and scientific expertise to support disease modeling, mechanistic biology, and drug discovery. To learn more, visit inventialifescience.com.

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