SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   SCHEDULE TO
                                (AMENDMENT NO. 2)
                                  (Rule 13e-4)

            TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                         PROGENICS PHARMACEUTICALS, INC.
                       (Name of Subject Company (Issuer))

                         PROGENICS PHARMACEUTICALS, INC.
                        (Name of Filing Person (Offeror))

                  Options Under Progenics Pharmaceuticals, Inc.
                 Amended and Restated 1996 Stock Incentive Plan
              to Purchase Common Stock, Par Value $0.0013 Per Share
                         (Title of Class of Securities)

                                   743187 10 6
                      (CUSIP Number of Class of Securities)
                            (Underlying Common Stock)

                               Philip K. Yachmetz
                          General Counsel and Secretary
                         Progenics Pharmaceuticals, Inc.
                           777 Old Saw Mill River Road
                            Tarrytown, New York 10591
                                 (914) 789-2800
                  (Name, address and telephone number of person
               authorized to receive notices and communications on
                            behalf of filing person)

                            CALCULATION OF FILING FEE






-----------------------------------------------------------------------
      Transaction valuation*                      Amount of filing fee
-----------------------------------------------------------------------
                                                   
           $7,025,000                                   $1,405**
-----------------------------------------------------------------------


* Calculated solely for purposes of determining the filing fee. This amount
assumes that options to purchase 468,500 shares of common stock of Progenics
Pharmaceuticals, Inc. having an exercise price of $20.00 will be issued in
exchange for currently outstanding options pursuant to this offer. The aggregate
value of such options was calculated based on the Black-Scholes option pricing
model. The amount of the filing fee, calculated in accordance with Rule 0-11 of
the Securities Exchange Act of 1934, as amended, equals 1/50th of one percent of
the value of the transaction.

**  Previously paid.
[ ] Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
and identify the filing with which the offsetting fee was previously paid.
Identify the previous filing by registration statement number, or the Form or
Schedule and the date of its filing.

                                                                                 

Amount Previously Paid:            Not applicable.   Filing party:               Not applicable.
Form or Registration No.:          Not applicable.   Date filed:                 Not applicable.


[ ] Check the box if the filing relates solely to preliminary communications
made before the commencement of a tender offer. Check the appropriate boxes
below to designate any transactions to which the statement relates:
[ ] third party tender offer subject to Rule 14d-1.
[X] issuer tender offer subject to Rule 13e-4.
[ ] going-private transaction subject to Rule 13e-3.
[ ] amendment to Schedule 13D under Rule 13d-2.
Check the following box if the filing is a final amendment reporting the results
of the tender offer. [X]









This Amendment No. 2 and Final Amendment to the Tender
Offer Statement on Schedule TO amends and supplements the Tender Offer Statement
on Schedule TO relating to an offer to employees by the Company to exchange
outstanding options to purchase shares of our common stock, par value $.0013
(the "Common Stock") granted on January 1, 2000 and January 7, 2000 and, solely
with regard to those employees hired on or between January 1, 2000 and February
28, 2001, options granted on such employees' original date of employment under
the Company's Amended and Restated 1996 Stock Incentive Plan to purchase shares
of Common Stock, for new options (the "New Options") to purchase shares of the
Common Stock to be granted under the same plan, upon the terms and subject to
the conditions described in the Offer to Exchange and the related Election
Concerning Exchange of Stock Options form (the "Election Form" and, together
with the Offer to Exchange, as they may be amended from time to time, the
"Offer")

Item 4.  Terms of the Transaction

Item 4 of the Schedule TO is hereby amended to add to following sentences:

The offer expired on June 23, 2001. We have accepted for cancellation options to
purchase 264,000 shares of Common Stock. We will issue the New Options to
purchase 264,000 shares of Common Stock in exchange for the options surrendered
in the exchange offer. In addition, on June 25, 2001, we issued new options to
purchase 31,600 shares of Common Stock, with an exercise price of $19.15 per
share, to eligible employees who chose not to participate in the exchange offer.

Item 12. Exhibits.

Item 12 of the Schedule TO is hereby amended and restated as follows so as to
add Exhibit (a)(6) attached hereto:

(a)      (1)      Offer to Exchange, dated May 25, 2001.*

         (2)      Form of Election Concerning Exchange of Stock Options.*

         (3)      Progenics Pharmaceuticals, Inc. Annual Report on Form 10-K
                  for its fiscal year ended December 31, 2000 filed with the
                  Securities and Exchange Commission on March 30, 2001 and
                  incorporated herein by reference.*

         (4)      Progenics Pharmaceuticals, Inc. Quarterly Report on Form 10-Q
                  for its fiscal quarter ended March 31, 2001, filed with the
                  Securities and Exchange Commission on May 15, 2001 and
                  incorporated herein by reference.*

         (5)      Memorandum to Employees from Paul J. Maddon, M.D., Ph.D.*

         (6)      Supplement, dated June 13, 2001, to Offer to Exchange,
                  dated May 25, 2001.*

         (7)      Memorandum to Employees, dated June 25, 2001, from
                  Philip K. Yachmetz, Esq.

(b)      Not applicable.

(d)      (1)      Progenics Pharmaceuticals, Inc. Amended and Restated 1996
                  Stock Incentive Plan filed as an exhibit to the Company's
                  Quarterly Report on Form 10-Q for its fiscal quarter ended
                  September 30, 1999 and incorporated herein by reference.*

(g)      Not applicable.

(h)      Not applicable.

-------------------------
*  Previously filed.


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                                    SIGNATURE

After due inquiry and to the best of my knowledge and belief, I certify that the
information set forth in this Schedule TO is true, complete and correct.
Progenics Pharmaceuticals, Inc.



                                                 /s/ PHILIP K. YACHMETZ, ESQ.
                                                 --------------------------
                                                 Philip K. Yachmetz, Esq.
                                                 General Counsel and Secretary
                                                 Date: June 28, 2001




















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