FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * BISCHOFBERGER NORBERT W   2. Issuer Name and Ticker or Trading Symbol GILEAD SCIENCES INC [GILD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) EVP, Research (Last) (First) (Middle) 333 LAKESIDE DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 10/25/2005 (Street) FOSTER CITY, CA 94404 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/25/2005   M   100,000 A $ 7.3985 591,573 D   Common Stock 10/25/2005   M   13,496 A $ 7.4063 605,069 D   Common Stock 10/25/2005   S   35,000 D $ 47.77 570,069 D   Common Stock 10/25/2005   S   15,000 D $ 47.76 555,069 D   Common Stock 10/25/2005   S   20,000 D $ 47.55 535,069 D   Common Stock 10/25/2005   S   10,000 D $ 47.57 525,069 D   Common Stock 10/25/2005   S   20,000 D $ 47.51 505,069 D   Common Stock 10/25/2005   G(1)   2,500 D $ 0 89,822 I by Trust Common Stock               800 I by Son Common Stock               800 I by Daughter

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Non-Qualified StockOption (right to buy)

$ 7.3985

10/25/2005

M

100,000

(2)

01/17/2011

Common Stock

100,000

$ 0

96,488

D

Incentive Stock Option (right to buy)

$ 7.4063

10/25/2005

M

13,496

(3)

04/05/2010

Common Stock

13,496

$ 0

0

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
BISCHOFBERGER NORBERT W 333 LAKESIDE DRIVE FOSTER CITY, CA 94404			EVP, Research

Signatures

/s/ Norbert W. Bischofberger		10/26/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Shares given as gifts to various not-for-profit organizations.
(2)	Options vested 20% on January 18, 2002, the first anniversary date of the grant. The balance vested quarterly through January 18, 2006.
(3)	Options vested 20% on April 5, 2001, the first anniversary date of the grant. The balance vested quarterly through April 5, 2005.

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