(Name
of Issuer)
Common
Stock, par value $0.0001 per share
|
||
(Title
of Class of Securities)
004225108
|
||
(CUSIP
Number)
|
||
December
31, 2007
|
||
(Date
of Event which Requires Filing of this
Statement)
|
CUSIP
No. 004225108
|
1
|
NAMES
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Felix
J. Baker
|
||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See
Instructions) (a)
¨
(b)
¨
|
||
3
|
SEC
USE ONLY
|
||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
-0-
|
|
6
|
SHARED
VOTING POWER
2,283,578
|
||
7
|
SOLE
DISPOSITIVE POWER
-0-
|
||
8
|
SHARED
DISPOSITIVE POWER
2,283,578
|
||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON
2,283,578
|
||
10
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
¨
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
6.2%
|
||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
CUSIP
No. 004225108
|
1
|
NAMES
OF REPORTING PERSONS
I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Julian
C. Baker
|
||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a)
¨
(b)
¨
|
||
3
|
SEC
USE ONLY
|
||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
-0-
|
|
6
|
SHARED
VOTING POWER
2,283,578
|
||
7
|
SOLE
DISPOSITIVE POWER
-0-
|
||
8
|
SHARED
DISPOSITIVE POWER
2,283,578
|
||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON
2,283,578
|
||
10
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
¨
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
6.2%
|
||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
Item 1(a) |
Name
of Issuer:
|
Item 1(b) |
Address
of Issuer’s Principal Executive
Offices:
|
Item 2(a) |
Name
of Person Filing:
|
Item 2(b) |
Address
of Principal Business Office or, if None,
Residence:
|
Name
|
Business
Address
|
|
Felix
J. Baker
|
667
Madison Avenue
New
York, NY 10065
|
|
Julian
C. Baker
|
667
Madison Avenue
New
York, NY 10065
|
Item 2(c) |
Citizenship:
|
Item 2(d) |
Title
of Class of Securities:
|
Item 2(e) |
CUSIP
Number:
|
Item
3.
|
If
this statement is filed pursuant to §§240.13d-1(b) or (c), check whether
the person filing is a:
N/A
|
Item 4. |
Ownership.
|
Name
|
Number
of Shares
|
Percent
of Class
Outstanding
|
|||||
Baker
Bros. Investments I, L.P.
|
20,354
|
0.1
|
%
|
||||
Baker
Bros. Investments II, L.P.
|
9,350
|
0.0
|
%
|
||||
Baker
Biotech Fund I, L.P.
|
581,875
|
1.6
|
%
|
||||
Baker
Brothers Life Sciences, L.P.
|
1,611,013
|
4.3
|
%
|
||||
14159,
L.P.
|
40,357
|
0.1
|
%
|
||||
Baker/Tisch
Investments, L.P.
|
20,629
|
0.1
|
%
|
||||
Total
|
2,283,578
|
6.2
|
%
|
Item 5. |
Ownership
of Five Percent or Less of a
Class.
|
Item 6. |
Ownership
of More than Five Percent on Behalf of Another
Person.
|
Item 7. |
Identification
and Classification of the Subsidiary Which Acquired the Security
Being
Reported on by the Parent Holding Company or Control
Person.
|
Item 8. |
Identification
and Classification of Members of the
Group.
|
Item 9. |
Notice
of Dissolution of Group.
|
Item 10. |
Certification.
|
/s/
Felix J. Baker
|
||
Felix
J. Baker
|
||
/s/
Julian C. Baker
|
||
Julian
C. Baker
|
/s/
Felix J. Baker
|
||
Felix
J. Baker
|
||
/s/
Julian C. Baker
|
||
Julian
C. Baker
|