Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Mueller Brian
 2. Date of Event Requiring Statement (Month/Day/Year)
03/02/2011		 3. Issuer Name and Ticker or Trading Symbol
BIOMARIN PHARMACEUTICAL INC [BMRN]
(Last)
(First)
(Middle)
C/O BIOMARIN PHARMACEUTICAL INC., 105 DIGITAL DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Corporate Controller
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NOVATO, CA 94949		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 1,112
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) 07/06/2006(1) 01/05/2016 Common Stock 15,000 $ 11.74 D  
Stock Option (right to buy) 05/20/2007(2) 11/19/2016 Common Stock 10,000 $ 17.54 D  
Stock Option (right to buy) 12/07/2007(3) 06/06/2017 Common Stock 9,500 $ 17.33 D  
Stock Option (right to buy) 12/27/2007(4) 06/26/2017 Common Stock 1,000 $ 17.89 D  
Stock Option (right to buy) 11/22/2008(5) 05/21/2018 Common Stock 11,000 $ 38.59 D  
Stock Option (right to buy) 06/17/2009(6) 12/16/2018 Common Stock 3,500 $ 17.86 D  
Stock Option (right to buy) 11/12/2009(7) 05/11/2019 Common Stock 25,000 $ 14.39 D  
Stock Option (right to buy) 11/12/2010(8) 05/11/2020 Common Stock 22,700 $ 21.51 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Mueller Brian
C/O BIOMARIN PHARMACEUTICAL INC.
105 DIGITAL DRIVE
NOVATO, CA 94949		       VP, Corporate Controller  

Signatures

/s/Laura Randall Woodhead, Attorney-in-Fact 03/11/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Original option grant vests 6/48ths on July 6, 2006 and 1/48th on the 6th of each month thereafter.
(2) Original option grant vests 6/48ths on May 20, 2007 and 1/48th on the 20th of each month thereafter.
(3) Original option grant vests 6/48ths on December 7, 2007 and 1/48th on the 7th of each month thereafter.
(4) Original option grant vests 6/48ths on December 27, 2007 and 1/48th on the 27th of each month thereafter.
(5) Original option grant vests 6/48ths on November 22, 2008 and 1/48th on the 22nd of each month thereafter.
(6) Original option grant vests 6/48ths on June 17, 2009 and 1/48th on the 17th of each month thereafter.
(7) Original option grant vests 6/48ths on November 12, 2009 and 1/48th on the 12th of each month thereafter.
(8) Original option grant vests 6/48ths on November 12, 2010 and 1/48th on the 12th of each month thereafter.

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